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Protein Requirements on GLP-1s

How much protein you need to preserve muscle mass during rapid weight loss—and strategies for hitting your target when appetite is gone.

Here's the problem: GLP-1 medications cause significant weight loss, but 25-40% of that weight can be lean mass (muscle). The solution is adequate protein intake combined with resistance training. But when you're barely hungry, getting enough protein is a real challenge.

How Much Protein You Need

The Recommendation
1.0 – 1.2 g protein per kg body weight
Example: 180 lb (82 kg) person → 82-98g protein daily

This is higher than the general RDA (0.8g/kg) because you're in a caloric deficit. Your body needs extra protein to preserve muscle during weight loss. Some experts recommend up to 1.5g/kg for those doing significant resistance training.

Best Protein Sources

Protein Content by Source
Chicken breast (4 oz)35g
Greek yogurt (1 cup)17g
Eggs (2 large)12g
Salmon (4 oz)25g
Cottage cheese (1 cup)28g
Protein shake20-30g
Deli turkey (3 oz)18g
Lentils (1 cup cooked)18g

The Challenge

When your appetite is suppressed and you're eating 1,000-1,200 calories a day, getting 80-100g of protein is genuinely difficult. You may only want to eat a few bites—and those few bites need to be protein-rich.

Strategies That Work
  • Protein first, always. Start every meal with your protein source before anything else.
  • Protein shakes are your friend. Easy to consume, high protein density. Use when solid food is unappealing.
  • Greek yogurt and cottage cheese. High protein, easy to eat, can be enhanced with protein powder.
  • Spread it out. 25-30g per meal/snack, 3-4 times daily. Don't try to get it all at once.
  • Keep protein snacks accessible. String cheese, jerky, hard-boiled eggs, protein bars.

Signs You're Not Getting Enough

If you're experiencing these, prioritize protein even more aggressively and consider working with a dietitian.

The Bottom Line
Aim for 1.0-1.2g protein per kg body weight daily—higher than normal because you're in a deficit. This is hard when appetite is suppressed. Strategies: eat protein first at every meal, use protein shakes, keep easy protein snacks on hand, and spread intake across 3-4 eating occasions. Combined with resistance training, adequate protein is essential to preserving muscle during GLP-1 weight loss.
Sources
  1. Protein requirements during weight loss: International Society of Sports Nutrition.
  2. Muscle preservation during caloric restriction research.
  3. Clinical nutrition guidelines for obesity treatment.