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Your First Week on GLP-1s: A 7-Day Meal Plan

Starting semaglutide or tirzepatide? This week-by-week meal guide focuses on nausea-friendly foods, protein prioritization, and easy meals when your appetite is unpredictable.

Week 1 Priorities

Week 1 Eating Principles

The first week on GLP-1 medication can be unpredictable. Your appetite may change dramatically—or not much at all yet. This meal plan is designed for flexibility:

GoalTargetWhy
Protein60-80g minimum/dayPreserve muscle, maximize satiety
Fiber25-30g/dayGut health, fullness (but may worsen GI symptoms—adjust)
Water64-80 oz/dayPrevent constipation, manage nausea
Calories~1200-1600Natural reduction from medication; don't force more
Pro Tip

Protein first, always. At every meal, eat your protein source before carbs or vegetables. This ensures you get adequate protein even when you can only eat a few bites.

Nausea-Friendly Foods

If you experience nausea (common days 2-4 after injection), these foods are typically well-tolerated:

Foods to Avoid Week 1

The 7-Day Meal Plan

Day 1 (Injection Day)
Breakfast
Greek Yogurt Parfait
1 cup plain Greek yogurt + ¼ cup berries + 1 tbsp chia seeds
Protein: 20g
Lunch
Turkey & Cheese Roll-Ups
4 oz deli turkey + 2 slices Swiss cheese + cucumber slices + mustard
Protein: 28g
Dinner
Baked Salmon with Vegetables
4 oz salmon + 1 cup steamed broccoli + ½ cup quinoa
Protein: 28g
Snack
Cottage Cheese
½ cup cottage cheese with a few crackers
Protein: 12g

Day 1 Total: ~88g protein

Day 2 (Post-Injection)

Nausea may begin—portions smaller, foods gentler

Breakfast
Scrambled Eggs
2 eggs scrambled + 1 slice whole grain toast
Protein: 14g
Lunch
Chicken Soup
1.5 cups chicken noodle soup (or bone broth with shredded chicken)
Protein: 15g
Dinner
Plain Grilled Chicken
4 oz chicken breast + ½ cup mashed potatoes + steamed carrots
Protein: 26g
Snack
String Cheese + Apple
2 string cheese sticks + ½ apple
Protein: 14g

Day 2 Total: ~69g protein

Day 3
Breakfast
Protein Smoothie
1 scoop protein powder + 1 cup almond milk + ½ banana + 1 tbsp peanut butter
Protein: 28g
Lunch
Tuna Salad on Greens
1 can tuna + 1 tbsp mayo + mixed greens + cherry tomatoes
Protein: 25g
Dinner
Turkey Meatballs
4 turkey meatballs + ½ cup marinara + small side salad
Protein: 24g
Snack
Hard-Boiled Eggs
2 hard-boiled eggs
Protein: 12g

Day 3 Total: ~89g protein

Day 4
Breakfast
Cottage Cheese Bowl
1 cup cottage cheese + sliced peaches + sprinkle of granola
Protein: 24g
Lunch
Rotisserie Chicken
4 oz rotisserie chicken (white meat) + side of hummus + raw veggies
Protein: 28g
Dinner
Shrimp Stir-Fry
5 oz shrimp + mixed vegetables + ½ cup brown rice (light sauce)
Protein: 26g
Snack
Greek Yogurt
½ cup plain Greek yogurt
Protein: 10g

Day 4 Total: ~88g protein

Day 5
Breakfast
Egg Muffins
2 pre-made egg muffins (eggs + cheese + vegetables)
Protein: 16g
Lunch
Deli Meat Wrap
Low-carb wrap + 4 oz ham + cheese + lettuce + tomato
Protein: 26g
Dinner
Baked Cod
5 oz cod + roasted zucchini + small baked potato
Protein: 28g
Snack
Beef Jerky
1 oz beef jerky
Protein: 10g

Day 5 Total: ~80g protein

Day 6
Breakfast
Protein Pancakes
2 protein pancakes + sugar-free syrup + 2 turkey sausage links
Protein: 24g
Lunch
Chicken Caesar Salad
4 oz grilled chicken + romaine + light Caesar dressing + parmesan
Protein: 30g
Dinner
Lean Beef Tacos
4 oz lean ground beef + 2 small corn tortillas + salsa + cheese
Protein: 28g
Snack
Edamame
1 cup edamame (shelled)
Protein: 17g

Day 6 Total: ~99g protein

Day 7
Breakfast
Veggie Omelet
3-egg omelet with spinach, mushrooms, cheese
Protein: 21g
Lunch
Leftover Protein Bowl
Mix of week's leftover proteins + fresh greens + olive oil dressing
Protein: ~25g
Dinner
Pork Tenderloin
4 oz pork tenderloin + roasted Brussels sprouts + ½ cup sweet potato
Protein: 26g
Snack
Protein Bar
1 protein bar (choose 15g+ protein, <10g sugar)
Protein: 15g

Day 7 Total: ~87g protein

Week 1 Shopping List

Proteins

Produce

Week 1 Success
Your first week on GLP-1 medication is about adaptation, not perfection. Prioritize protein at every meal (eat it first), stay hydrated, and listen to your body. If you're nauseous, stick to bland, simple foods—it usually improves within a few days. Don't force yourself to eat large portions; the reduced appetite is the medication working. Aim for 60-80g protein minimum daily to preserve muscle mass. This meal plan provides structure, but feel free to swap similar protein sources based on what sounds appealing. Next week, as your body adjusts, you can expand variety and explore more recipes.
Sources
  1. Academy of Nutrition and Dietetics. Protein Requirements During Weight Loss. 2023.
  2. Obesity Medicine Association. Dietary Recommendations for Obesity Pharmacotherapy. 2024.
  3. Heymsfield SB, et al. Weight Loss Composition. Am J Clin Nutr. 2014.
  4. Novo Nordisk. Wegovy Patient Guide. 2024.
  5. Eli Lilly. Zepbound Patient Guide. 2024.
  6. Wharton S, et al. Nutrition and GLP-1 Therapy. Obesity. 2023.