GLP-1 Injection Technique: Sites, Rotation, and Pro Tips

If you're using a weekly GLP-1 injection like Wegovy, Ozempic, Zepbound, or Mounjaro—or a compounded version from a vial—proper injection technique matters. Good technique means better absorption, less discomfort, and avoiding long-term issues like scar tissue buildup.

Injection Sites: Where to Inject

GLP-1 medications are subcutaneous injections—they go into the fat layer just under your skin, not into muscle. Three areas are FDA-approved for self-injection:

Site-Specific Notes

Stomach: The most common choice. Stay at least 2 inches away from your belly button. Some patients report more intense GI side effects (nausea, cramping) when injecting here—though this isn't clinically proven, it's a common anecdote worth trying if you're struggling.

Thigh: Many patients find this the easiest site for self-injection. Use the middle third of your thigh (front or slightly outer). Absorption may be slightly slower than stomach, but the difference is clinically insignificant for weekly medications.

Arm: Good for rotation but hard to reach yourself. The fatty area on the back of your upper arm works well—you may need a partner or practice in the mirror.

Step-by-Step Injection Process

1. Wash Your Hands

   20+ seconds with soap and water. This is non-negotiable—you're puncturing your skin.
2. Gather Supplies

   Medication (pen or vial), alcohol wipes, new syringe (if using vials), sharps container.
3. Check the Medication

   Solution should be clear and colorless. If it's cloudy, has particles, or looks off-color—don't use it.
4. Clean the Injection Site

   Wipe with alcohol pad in circular motion. Let it dry completely (10-15 seconds)—injecting into wet alcohol stings.
5. Pinch the Skin

   Gently pinch a fold of skin at your chosen site. This lifts the fat layer away from muscle.
6. Insert the Needle

   90-degree angle, one smooth motion. Don't hesitate or "jab"—a confident, steady insertion hurts less.
7. Inject Slowly

   Press the plunger steadily. For pens, hold the button for 10 seconds after the dose counter shows zero.
8. Remove and Dispose

   Pull straight out. Don't rub the site—gentle pressure with a cotton ball if there's any bleeding. Dispose of needle in sharps container.

Site Rotation: Why It Matters

Injecting in the same spot repeatedly causes lipohypertrophy—hardened lumps of fatty tissue that form under the skin. These lumps don't absorb medication properly, which can lead to inconsistent drug levels and reduced efficacy.

The rule: Never inject in the exact same spot twice in a row. Move at least 1 inch from your previous injection site.

Some patients keep a simple log—date, site, any notes—in their phone or on the medication box. This prevents "did I already use that side?" confusion.

Pro Tips from Experienced Users

Reducing Injection Anxiety

Needle anxiety is real and common. Even people who've done hundreds of injections can feel it. Here's what helps:

For severe needle phobia: Talk to your provider. Some patients use prescription anti-anxiety medication before injections, or work with a therapist on desensitization. Oral GLP-1 options (like Rybelsus) exist but have different efficacy profiles.

Compounded Vials: Extra Considerations

If you're using a compounded GLP-1 from a vial (vs. a pre-filled pen), there are additional steps:

• Syringe selection: Typically insulin syringes—31 gauge, 5/16" or 1/2" needle. Your pharmacy should include these.
• Drawing medication: Clean vial top with alcohol. Draw air equal to your dose, inject air into vial, then draw medication.
• Check for bubbles: Tap the syringe to move bubbles to the top, push them out gently.
• Storage: Multi-dose vials must be refrigerated and used within the Beyond Use Date (typically 28-30 days after first puncture).

Pre-Injection Checklist